Reconstruction of the evolution phases of a landslide by using multi‑layer back‑analysis methods

Back analysis is the most common method to study landslide movements after the event, and it allows us to understand how a landslide evolved along the slope. This paper presents the back-analysis of the Pomarico landslide (Basilicata, Italy) that occurred on January 25th, 2019, on the southwestern slope of the Pomarico hill. The landslide, of rotational clayey retrogressive type—planar sliding, evolved in different phases until it caused a paroxysmal movement in the early afternoon on January 29th, 2019. The landslide caused the collapse of a bulkhead (built at the end of the twentieth century) and of some buildings along the village’s main road. In this paper, a multi-layer back-analysis study is presented, based on the limit equilibrium model (LEM), applying the solution proposed by Morgenstern and Price in Geotechnique 15(1):79–93zh, (1965) and implemented in the freeware software SSAP 2010. The analysis allowed the reconstruction of the entire landslide evolution, using geotechnical parameters obtained from both laboratory and in situ tests, and data from the literature. The application of multilayer back-analysis made it possible to avoid the homogenisation of the layers, modelling the event according to the real conditions present on the slope. The use of the SSAP software made it possible to curb the problem related to the theoretical limitation of the shape of the rupture surfaces, by evaluating independently the friction angle locally and by discarding all those surfaces, which, due to this problem, presented a non-reliable factor of safety (FS) value. The modelling revealed a slope that is highly unstable as the height of the water table changes. The FS calculated under water table conditions close to ground level was less than 1 (FS = 0.98), simulating the first landslide movement (November 2018). The subsequent model reconstructed the critical surface responsible for the January 2019 movement and calculated the FS present on the slope (FS = 1.01). Eventually, the paroxysmal event on January 29th, 2019, was modelled, returning an FS of 0.83, and a sliding surface that sets below the bulkhead, causing its failure. Furthermore, the modelling of the slope in the presence of adequate retaining structures demonstrated the (non-) effectiveness of the retaining wall system represented by the bulkhead. The proposed method of analysis suggests further applications in similar complex multi-layer soil-structure interaction scenarios

Review on the Geophysical and UAV-Based Methods Applied to Landslides

peer reviewedLandslides (LS) represent geomorphological processes that can induce changes over time in the physical, hydrogeological, and mechanical properties of the involved materials. For geohazard assessment, the variations of these properties might be detected by a wide range of non-intrusive techniques, which can sometimes be confusing due to their significant variation in accuracy, suitability, coverage area, logistics, timescale, cost, and integration potential; this paper reviews common geophysical methods (GM) categorized as Emitted Seismic and Ambient Noise based and proposes an integrated approach between them for improving landslide studies; this level of integration (among themselves) is an important step ahead of integrating geophysical data with remote sensing data. The aforementioned GMs help to construct a framework based on physical properties that may be linked with site characterization (e.g., a landslide and its subsurface channel geometry, recharge pathways, rock fragments, mass flow rate, etc.) and dynamics (e.g., quantification of the rheology, saturation, fracture process, toe erosion, mass flow rate, deformation marks and spatiotemporally dependent geogenic pore-water pressure feedback through a joint analysis of geophysical time series, displacement and hydrometeorological measurements from the ground, air and space). A review of the use of unmanned aerial vehicles (UAV) based photogrammetry for the investigation of landslides was also conducted to highlight the latest advancement and discuss the synergy between UAV and geophysical in four possible broader areas: (i) survey planning, (ii) LS investigation, (iii) LS dynamics and (iv) presentation of results in GIS environment. Additionally, endogenous source mechanisms lead to the appearance of deformation marks on the surface and provide ground for the integrated use of UAV and geophysical monitoring for landslide early warning systems. Further development in this area requires UAVs to adopt more multispectral and other advanced sensors where their data are integrated with the geophysical one as well as the climatic data to enable Artificial Intelligent based prediction of LS

A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane: Results From a Prospective Study

Currently there are no reliable biomarkers to predict outcome of exemestane treatment. We designed a prospective study to investigate whether constitutive genetic background might affect response to therapy. In a population of 302 advanced breast cancer patients treated with exemestane we showed that a 5-polymorphism-based genetic score could be used to identify patients with different risks of progression and death.Introduction: Approximately 50% of locally advanced or metastatic breast cancer (MBC) patients treated with first-line exemestane do not show objective response and currently there are no reliable biomarkers to predict the outcome of patients using this therapy. The constitutive genetic background might be responsible for differences in the outcome of exemestane-treated patients. We designed a prospective study to investigate the role of germ line polymorphisms as biomarkers of survival. Patients and Methods: Three hundred two locally advanced or MBC patients treated with first-line exemestane were genotyped for 74 germ line polymorphisms in 39 candidate genes involved in drug activity, hormone balance, DNA replication and repair, and cell signaling pathways. Associations with progression-free survival (PFS) and overall survival (OS) were tested with multivariate Cox regression. Bootstrap resampling was used as an internal assessment of results reproducibility. Results: Cytochrome P450 19A1-rs10046TC/CC, solute carrier organic anion transporter 1B1-rs4149056TT, adenosine triphosphate binding cassette subfamily G member 2-rs2046134GG, fibroblast growth factor receptor-4-rs351855TT, and X-ray repair cross complementing 3-rs861539TT were significantly associated with PFS and then combined into a risk score (0-1, 2, 3, or 4-6 risk points). Patients with the highest risk score (4-6 risk points) compared with ones with the lowest score (0-1 risk points) had a median PFS of 10 months versus 26.3 months (adjusted hazard ratio [AdjHR], 3.12 [95% confidence interval (CI), 2.18-4.48]; P < .001) and a median OS of 38.9 months versus 63.0 months (AdjHR, 2.41 [95% CI, 1.22-4.79], P = .012), respectively. Conclusion: In this study we defined a score including 5 polymorphisms to stratify patients for PFS and OS. This score, if validated, might be translated to personalize locally advanced or MBC patient treatment and management

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV

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Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

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Measurement of the top quark mass using charged particles in pp collisions at root s=8 TeV

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